Toggle Location Modal

8 Reversible Causes of Cardiac Arrest - 4Hs and 4Ts

WhatsApp
Medically Reviewed by Dr. Aman Priya Khanna
Written by Rajath R Prabhu, last updated on 16 January 2023| min read
8 Reversible Causes of Cardiac Arrest - 4Hs and 4Ts

Quick Summary

  • Cardiac arrest is a life-threatening condition in which the heart stops beating suddenly.
  • It can be caused by underlying cardiac diseases such as arrhythmia, heart failure, or ischaemic heart disease.
  • It can also be caused by other reversible causes such as electrolyte imbalances, hypothermia, and toxins.

Cardiac arrest or sudden cardiac arrest comes without warning. It is a terrifying, life-threatening condition in which the heart stops beating suddenly. As a result, the heart stops pumping blood, cutting the oxygen supply to your body’s organs. Cardiac arrest can be fatal if you do not receive immediate help with oxygen supply to your brain and other vital organs. 

Generally, cardiac arrests are caused due to underlying cardiac diseases such as arrhythmia, heart failure, or ischaemic heart disease. However, it can also occur due to other causes that can be reversed with proper treatment. The following blog discusses these reversible causes of cardiac arrest, including their symptoms, causes, diagnosis, and treatment. Combined with CPR and defibrillation, treating these reversible causes can increase your chances of surviving a sudden cardiac arrest.

What are the Reversible Causes of a Cardiac Arrest?

Even one second spent trying to treat the cause of cardiac arrest can delay the initiation of cardiopulmonary resuscitation (CPR), which could lead to death. Therefore, the treatment for reversible causes of cardiac arrest is advised after the initial procedures to restart the heart. The 8 reversible causes of cardiac arrest are divided into two groups: four causes that start with “H” and four causes that start with “T”.

Book Consultation

The 4Hs of Reversible Causes of Cardiac Arrest

The 4Hs of reversible causes of cardiac arrest include Hypoxia (lack of oxygen to the body), Hypovolemia (low blood volume), Hypokalemia (low potassium levels), and Hypothermia (low body temperature). It is important to identify and treat these potential causes as soon as possible in order to improve the chances of successful resuscitation.

Hypoxia

One of the leading causes of cardiac arrest, hypoxia, occurs when the oxygen level drops in the body tissues. Oxygen is required to produce energy, and it helps tissues and organs perform their required function. Low oxygen levels for a long time (prolonged hypoxia) can damage your organs, such as the brain and heart. As per current research, hypoxia can cause a fall in blood pressure, leading to bradycardia (a slow heart rate) and finally progressing to a cardiac standstill. 

The symptoms and causes of hypoxia include:

Symptoms Causes
  1. Headache
  2. Restlessness
  3. Anxiety and confusion
  4. Tachypnea: rapid breathing
  5. Tachycardia: rapid heart rate
  6. Dyspnea: shortness of breath

When severe, hypoxia can cause additional symptoms, such as:

  1. Bradycardia: slow heart rate
  2. Cyanosis: bluish skin, lips, and nails

Conditions that can cause hypoxia include the following:

  1. Airway obstruction
  2. Anaemia: low haemoglobin
  3. Asthma
  4. Asphyxia: insufficient oxygen supply to the body as a result of abnormal breathing
  5. Bronchitis: inflammation of bronchial tubes
  6. Heart failure
  7. Congenital heart defects
  8. Emphysema: lung disease that causes shortness of breath
  9. Pneumonia
  10. Pneumothorax: collapsed lung
  11. Pulmonary embolism: blood clot in the lungs
  12. Pulmonary oedema (fluid in the lungs)
  13. Pulmonary fibrosis (lung scarring)
  14. Sleep apnea (sleep disorder in which breathing stops and starts repeatedly)

The following table shows the diagnosis and management of this reversible cause of cardiac arrest. 

Diagnosis Treatment
  1. Physical exam: It includes listening to your lungs and heart and checking your skin, lips, and nails to see if they are bluish
  2. Pulse oximetry: The doctor places a sensor on your finger to measure the oxygen level in the blood
  3. Pulmonary function test: The doctor asks you to blow out into a mouthpiece connected to a machine that measures the functioning of your lungs
  4. Arterial blood gas test: The doctor uses a thin needle to draw blood from your artery
  5. Six-minute walk test: Measures the distance you can walk on a hard, flat surface in six minutes. The test helps to determine your heart and lung function
  6. Imaging tests: X-rays and CT scans get images of the internal organs, helping determine the cause of hypoxia
  1. Inhaled steroids or oral medications to open airways and treat asthma
  2. Medications to reduce excessive fluid in the lungs
  3. Proper oxygenation through a small plug in your nose or a mask that covers the nose and mouth
  4. Mechanical ventilation for sudden onset of hypoxia

Hypovolemia

Fluids in the body are essential to keep the organs functioning. Hypovolemia occurs when your body loses fluids, such as blood or water. Out of the 50-60% fluid consistency in the body, you lose over 15% of fluids from the body during hypovolemia. Due to severe fluid loss, the heart stops pumping blood, and other organs stop functioning. 

The symptoms and causes of hypovolemia include:

Symptoms Causes
  1. Dry mouth and skin
  2. Dizziness
  3. Fatigue
  4. Unable to urinate or darker urine than normal
  5. Muscle cramps

Severe symptoms of hypovolemic shock include:

  1. Difficult breathing or rapid breathing
  2. Excessive sweating
  3. Confusion
  4. Unconsciousness
  5. Cyanosis: bluish skin and lips
  6. Low body temperature
  7. Low blood pressure

Loss of blood or fluid from the body is the major cause of hypovolemia, which may occur due to the following:

  1. Illness: A condition that causes persistent vomiting or diarrhoea
  2. External bleeding: An external burn, injury, cut, or wound
  3. Internal bleeding: An underlying condition that results in blood loss within the body, such as gastrointestinal bleeding or ruptured aortic aneurysm
  4. Excessive sweating: While participating in strenuous activities
  5. Malnutrition or dehydration: Lack of water and salt intake can reduce blood volume

The diagnosis and treatment for hypovolemia include:

Diagnosis

Treatment

  1. Physical examination: The doctor will examine the skin and mucous membrane in your nose, mouth, and tongue to check for dryness
  2. Pulse, blood pressure, and body temperature: The doctor will take your vitals while sitting and standing and notice the change in symptoms
  3. Blood and urine tests: To measure kidney function
  4. Focused Assessment with Sonography for Trauma: Ultrasound to identify internal bleeding
  5. Echocardiogram: Ultrasound of the heart

The goal of hypovolemia treatment is to increase the amount of fluid in the body through fluid replacement, which includes:

  1. Blood transfusion: Donor blood is used to replace lost fluid in the body
  2. Intravenous colloids: Large molecules injected into the blood through a tube
  3. Intravenous crystalloids: Low-cost salt solutions with small molecules injected into the blood through a tube

Hyperkalemia/ Hypokalemia

Electrolyte disorders, such as hyperkalaemia and hypokalaemia, are reversible causes of cardiac arrest. Hyperkalemia is a condition where the potassium level in the body is abnormally high, i.e., more than 5.5 mmol/L. Too much potassium in the body can damage the heart and cause a heart attack. On the other hand, hypokalaemia refers to a low blood potassium level in the body, i.e., below 2.5 mmol/L. Over time, low potassium levels can cause problems such as abnormal heart rhythm, muscle weakness, and paralysis. 

The symptoms and causes of hyperkalaemia and hypokalaemia include:

  Symptoms Causes
Hyperkalaemia
  1. Pain in the abdomen and diarrhoea
  2. Heart palpitations or arrhythmia
  3. Chest pain
  4. Nausea and vomiting
  5. Muscle weakness
  1. Kidney disease
  2. Metabolic acidosis
  3. Diabetes
  4. Endocrine disorders
  5. High-potassium diet
  6. Medications that contain potassium
Hypokalaemia
  1. Heart palpitations
  2. Fatigue
  3. Constipation
  4. Numbness and tingling
  5. Severe muscle weakness
  6. Muscle twitches
  7. Muscle cramps
  8. Lightheadedness
  9. Low blood pressure
  10. Arrhythmia
  11. Excessive thirst
  12. Excessive urination
  1. Chronic kidney disease
  2. Metabolic alkalosis
  3. Diarrhoea
  4. Vomiting
  5. Low magnesium levels
  6. Excessive sweating
  7. Eating disorders like bulimia nervosa
  8. Alcohol use disorder
  9. Diuretics (water pills)
  10. Adrenal disorders like Cushing’s syndrome

The diagnosis and treatment for hyperkalaemia and hypokalaemia include:

  Diagnosis Treatment
Hyperkalaemia
  1. Serum potassium test: To measure potassium levels in the blood
  2. Electrocardiogram: Shows changes in heart rhythm as a result of hyperkalaemia
  1. Diuretics: Water pills that make you pee more often
  2. IV therapy: IV infusions of calcium to protect the heart and IV infusion of insulin to move potassium into the blood cells
  3. Dialysis: Helps the kidney remove excess potassium from your blood
Hypokalaemia
  1. Blood test: To check potassium levels in the blood
  2. Comprehensive metabolic panel: A group of blood tests to check your body’s kidney function and electrolyte balance
  3. Electrocardiogram: To measure abnormal heart rhythm
  1. Oral potassium supplements: For mild hypokalaemia
  2. Intravenous potassium: For more severe cases

Hypothermia

Hypothermia is an emergency condition in which the body produces less heat than it loses heat, leading to an extremely low body temperature. As opposed to the normal body temperature of about 98.6℉, the body temperature falls below 95℉ in hypothermia. This severe fall in body temperature can cause complete heart failure and eventually lead to death. 

The symptoms and causes of hypothermia include:

Symptoms Causes
  1. Shivering
  2. Slowed breathing
  3. Slurred speech
  4. Lack of coordination or clumsiness
  5. Weak pulse
  6. Confusion or memory loss
  7. Drowsiness
  8. Loss of consciousness

Cold weather conditions or prolonged exposure to an environment colder than your body are the primary causes of hypothermia. Conditions that lead to hypothermia include:

  1. Staying out in the cold for a prolonged period
  2. Wearing clothes that aren’t warm enough for the cold weather
  3. Falling into water or drowning
  4. Not being able to get out of wet clothes or moving to a warm location

The diagnosis and treatment of hypothermia include:

Diagnosis Treatment

The diagnosis of the condition is generally apparent based on the person’s physical signs. The doctor may order blood tests to confirm hypothermia and its severity. 

The treatment aims to increase body temperature to a normal range. The treatment options include:

  1. Remove wet clothing
  2. Move the person out of the cold
  3. Cover the person with blankets
  4. Offer warm, nonalcoholic, and non-caffeinated beverages if the person can swallow
  5. Use warm compresses
  6. Medical treatment: Such as warm intravenous fluids, blood rewarming, and airway rewarming

The 4Ts of Reversible Causes of Cardiac Arrest

The "4 Ts" of reversible causes of cardiac arrest are Toxins, Trauma, Tamponade and Thrombosis:

Tension Pneumothorax

Tension pneumothorax is the first ‘T’ of 4H and 4T in cardiac arrest. This condition develops when air builds up in the pleural space (between the lungs and inside the chest cavity). This buildup of air causes a shift in the mediastinum (space in the chest that holds the heart and other important structures), leading to haemodynamic compromise. 

The symptoms and causes of tension pneumothorax include:

Symptoms and Signs

Causes
  1. Acute chest pain
  2. Severe shortness of breath
  3. Shallow breathing
  4. Cyanosis
  5. Tracheal deviation from the affected side
  6. Absent unilateral breath sounds
  7. Subcutaneous emphysema: when air gets into tissues under the skin
  1. Traumatic tension, such as an open chest wound (gunshot or stab wound) or closed trauma (rib fracture)
  2. Mechanical ventilation: creates an imbalance of air pressure within the chest

The diagnosis and treatment for this reversible cause of cardiac arrest include:

Diagnosis

Treatment

  1. Chest X-ray: Helps determine radiological signs, such as increased transparency of the affected side, increased rib separation, or collapse of the affected lung
  2. Ultrasound imaging: To identify pneumothorax and confirm the diagnosis
  1. Needle decompression or needle thoracostomy: The doctor inserts a needle into the pleural cavity to decompress tension pneumothorax
  2. Chest tube insertion: A flexible chest tube attached to a one-way valve device is inserted into the air-filled space to remove air from the chest cavity. 

Thrombosis

Thrombosis is one of the 8 reversible causes of cardiac arrest. It is a serious condition in which one or more blood clots form in the blood vessels, obstructing the blood flow. The two types of thrombosis that generally cause cardiac arrest include coronary thrombosis and pulmonary embolism. Coronary thrombosis occurs when blood clots block the coronary artery in the heart, often leading to a heart attack or stroke. On the other hand, pulmonary embolism occurs when the blood clots block a pulmonary artery in the lungs. 

The symptoms and causes of coronary and pulmonary thrombosis include:

  Symptoms Causes

Coronary Thrombosis

  1. Chest pain
  2. Pain in the jaw, head, and ear
  3. Pain radiating down the left arm
  4. Tightness around the throat
  5. Shortness of breath
  6. Severe dizziness
  7. Fainting

It is caused by the breakage or rupture of plaque in the arteries. Plaque in the arteries is formed by cholesterol in the blood. 

Pulmonary Embolism

  1. Shortness of breath
  2. Anxiety
  3. Chest pain
  4. Irregular or rapid heartbeat
  5. Rapid breathing
  6. Lightheadedness
  7. Fainting
  8. Bluish skin
  9. Weak pulse
  10. Spitting up blood

It is most often caused by deep vein thrombosis. Several causes for blood clots in deep veins include:

  1. Injury or damage to blood vessels
  2. Inactivity for a long time
  3. Health conditions that cause blood to clot easily

The diagnosis and treatment for thrombosis include:

  Diagnosis Treatment

Coronary thrombosis 

  1. Electrocardiogram: reads irregularities in the electrical signals of the heart that might indicate a blood clot or heart attack
  2. Cardiac catheterisation: allows doctors to visualise the heart’s arteries and identify a clot
  1. Balloon angioplasty: To open the artery
  2. Stent placement: To widen the blood vessel and increase the blood flow
  3. Blood clot extraction: Useful when the blood clot is large

Pulmonary embolism

  1. Chest X-ray: Allows the doctor to see your heart and lungs
  2. Electrocardiography: Measures the heart’s electrical activity
  3. CT pulmonary angiography: First-choice diagnostic imaging method to look for blood clots in the lungs
  4. Ventilation-perfusion scan: Radioactive material is breathed and injected to look for airflow and blood flow in the lungs
  5. Pulmonary Angiography: The doctor uses contrast to look at the blood vessels in the lungs
  1. Anticoagulants: Blood thinners like warfarin that decrease the blood’s ability to clot
  2. Fibrinolytic therapy: Medicines called clot busters are given through an intravenous line to break down the clot
  3. Pulmonary embolectomy: Surgery done in severe cases when anticoagulation and fibrinolytic therapy does not work
  4. Percutaneous thrombectomy: A catheter is threaded through the blood vessel to break the embolism and pull it out

Tamponade (Cardiac)

Cardiac tamponade is the next ‘T’ in 4H and 4T of cardiac arrest. It occurs when fluid builds up in the pericardium (the sac that encloses the heart). As a result, this puts pressure on the chest leading to cardiac arrest. If not treated, cardiac tamponade is always fatal. 

The symptoms and causes of tamponade include:

Symptoms Causes
  1. Sharp pain in the chest
  2. Dizziness or lightheadedness
  3. Fainting
  4. Rapid breathing or trouble breathing
  5. Fast pulse
  6. Heart palpitations
  7. Changes in skin colour
  8. Jaundice
  9. Confusion or agitation

Signs include:

  1. Bulging neck veins
  2. Muffled heart sounds
  3. Low blood pressure
  1. Trauma to the chest or heart (inflammation or gunshot)

It can also be caused due to several diseases and conditions, such as:

  1. Heart attack
  2. Heart cancer
  3. Tuberculosis
  4. Inflammation or infection of the pericardium
  5. Ventricular wall rupture after a heart attack
  6. Chronic immune diseases (rheumatoid arthritis, lupus, etc.)
  7. Heart or kidney failure
  8. Hypothyroidism

The diagnosis and treatment of tamponade include:

Diagnosis Treatment
  1. Echocardiogram: Ultrasound waves to look inside your chest and heart
  2. Electrocardiogram: To detect the electrical activity of your heart
  3. Chest X-ray: To show fluid buildup around the heart
  4. CT scan: To examine the heart and circulatory problems
  1. Pericardiocentesis: A needle and catheter are inserted into the pericardium to drain fluid
  2. Thoracotomy: An incision is made between the ribs to open the chest and remove fluids

Toxins

Self-poisoning with toxins is the last reversible cause of cardiac arrest that obstructs the airway and causes respiratory arrest. While toxins in small amounts can be helpful, they can become poisonous in large amounts. Cardiac arrest caused due to toxins is rare. However, people suffering from this condition can benefit from an adequate resuscitation attempt. 

The symptoms and causes of toxin buildup in the body include:

Symptoms Causes
  1. Hair loss
  2. Fatigue
  3. Brain fog
  4. Bad breath
  5. Brittle toenails
  6. Weight gain
  7. Nausea
  8. Sleep impairment
  9. Memory difficulties
  1. Illicit drug use: Such as cocaine or opiates
  2. Medication overdose: Such as opioids, local anaesthetics, tricyclic antidepressants, benzodiazepines, beta-blockers, and calcium channel blockers

The following table shows the diagnosis and treatment of toxin overload:

Diagnosis

Treatment

  1. Core Temperature: Toxin overdose can cause hyper/hypothermia
  2. Electrocardiogram: A prolonged QT interval on ECG may indicate toxins
  3. Blood and urine test: To check for potential urea and electrolyte disturbance
  1. Activated charcoal: Charcoal stops the poison from being absorbed in the blood
  2. Antidotes: Substances that prevent or reverse the effect of poison
  3. Supportive measures: Like ventilator until the return of spontaneous circulation is achieved

Why is it Essential to Treat the 8 Reversible Causes of Cardiac Arrest?

The basis of cardiopulmonary resuscitation (CPR) is to encourage the return of spontaneous circulation (ROSC). It involves restarting the heart with proper electrical signals and blood flow to the body. If left unchecked, the reversible causes of cardiac arrest can cause a prolonged interval between the arrest and ROSC, decreasing the chances of survival. Therefore, it is important to treat these causes in the minutes following cardiac arrest. 

Takeaway

It is important to understand the above-mentioned reversible causes of cardiac arrest. Why? Because treating these causes can improve the chances of survival after a cardiac arrest. Understanding these causes and their management is key to optimal care that will likely lead to positive outcomes. 

If you have any more doubts about the 4H and 4T in cardiac arrest, you can contact an HexaHealth expert TODAY! Our team will connect you with the right doctors for appropriate treatment. 

Frequently Asked Questions

Reversible causes of cardiac arrest are underlying causes that can be reversed with treatment. If the cause of a cardiac arrest is reversible, reversing the cause can reverse the arrest.
WhatsApp

The 8 reversible causes of cardiac arrest include:

  1. Hypoxia
  2. Hypovolemia
  3. Hyper/Hypokalaemia
  4. Hypothermia
  5. Thrombosis
  6. Tension Pneumothorax
  7. Cardiac Tamponade
  8. Toxins
WhatsApp

The 5H and 5T of cardiac arrest is a way to remember the reversible causes, which include:

  1. Hypoxia
  2. Hypovolemia
  3. Hyper/hypokalaemia
  4. Hypothermia
  5. Hydrogen ion (acidosis)
  6. Tension pneumothorax
  7. Thrombosis (coronary)
  8. Thrombosis (pulmonary)
  9. Tamponade (cardiac)
  10. Toxins
WhatsApp
CPR should be stopped after 20 minutes if there is no return of spontaneous circulation or viable cardiac rhythm re-established. Furthermore, it should be stopped when no reversible causes of cardiac arrest are present that can potentially change the outcome.
WhatsApp
CPR is administered to a patient when a pulse is not identified within ten seconds. The pulse should be checked every two minutes during CPR. CPR is administered again if a pulse does not become available.
WhatsApp

CPR with compressions should be given when there is no breathing or pulse. However, when the patient has a pulse but is not breathing properly, ventilation should be provided without compressions (rescue breathing). For adults, one breath should be given every five to six seconds. For children, one breath should be given every three to five seconds. 

WhatsApp

No, CPR cannot restart a stopped heart. It is only a temporary measure to provide a minimal supply of oxygen to your brain and other organs. Defibrillation is the only effective way to re-establish a regular heartbeat during cardiac arrest. 

WhatsApp
Yes, CPR should be performed when there is a weak pulse and no effective heartbeat. However, before beginning, you must determine whether the person is conscious or unconscious.
WhatsApp

Doctors hit the chest or perform a precordial chest thump before CPR in response to witnessed ventricular fibrillation or ventricular tachycardia. It aims to restore organised electrical cardiac activity and move the patient to a more stable rhythm. 

WhatsApp
According to professionals, giving CPR to an alive person has no adverse effects. The chances of harming a person with a normal heartbeat by pressing on their chest are unlikely.
WhatsApp
When the heart stops, it stops pumping blood throughout the body. All brain activity is believed to cease by about three to four minutes from the time the heart stops due to lack of oxygen
WhatsApp

If CPR is performed within six minutes of cardiac arrest, the brain might survive the lack of oxygen. However, after six minutes without CPR, the brain begins to die. The greatest chance of survival and keeping the brain alive is within 16 to 24 minutes of cardiac arrest. With new advances such as mechanical CPR, the brain can stay alive and see more positive outcomes for more than 20 minutes. 

WhatsApp

The CPR survival rate is about 12% for cardiac arrests outside the hospital. On the other hand, the survival rate is between 24% and 40% for cardiac arrests in the hospital. 

WhatsApp

A non-reversible cause of cardiac arrest is a condition that cannot be treated or reversed, resulting in the individual's death. Some examples of non-reversible causes of cardiac arrest include sudden cardiac death, traumatic injury, an overdose of certain drugs, and Severe blood loss.

WhatsApp

The 5 H's refer to five common causes of cardiac arrest: Hypoxia, Hypovolemia, Hydrogen ion (acidosis), Hyperkalemia, and Hypothermia.

WhatsApp

Last Updated on: 16 January 2023

Disclaimer: The information provided here is for educational and learning purposes only. It doesn't cover every medical condition and might not be relevant to your personal situation. This information isn't medical advice, isn't meant for diagnosing any condition, and shouldn't replace talking to a certified medical or healthcare professional.

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Rajath R Prabhu

Rajath R Prabhu

MSc. Clinical Research I PG Diploma in Public Health Services Management

3 Years Experience

His work in medical content writing and proofreading is noteworthy. He has also contributed immensely to public health research and has authored four scientific manuscripts in international journals. He was assoc...View More

Book Consultation

aiChatIcon