Cardiac arrest or sudden cardiac arrest comes without warning. It is a terrifying, life-threatening condition in which the heart stops beating suddenly. As a result, the heart stops pumping blood, cutting the oxygen supply to your body’s organs. Cardiac arrest can be fatal if you do not receive immediate help with oxygen supply to your brain and other vital organs.
Generally, cardiac arrests are caused due to underlying cardiac diseases such as arrhythmia, heart failure, or ischaemic heart disease. However, it can also occur due to other causes that can be reversed with proper treatment. The following blog discusses these reversible causes of cardiac arrest, including their symptoms, causes, diagnosis, and treatment. Combined with CPR and defibrillation, treating these reversible causes can increase your chances of surviving a sudden cardiac arrest.
Even one second spent trying to treat the cause of cardiac arrest can delay the initiation of cardiopulmonary resuscitation (CPR), which could lead to death. Therefore, the treatment for reversible causes of cardiac arrest is advised after the initial procedures to restart the heart. The 8 reversible causes of cardiac arrest are divided into two groups: four causes that start with “H” and four causes that start with “T”.
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The 4Hs of reversible causes of cardiac arrest include Hypoxia (lack of oxygen to the body), Hypovolemia (low blood volume), Hypokalemia (low potassium levels), and Hypothermia (low body temperature). It is important to identify and treat these potential causes as soon as possible in order to improve the chances of successful resuscitation.
One of the leading causes of cardiac arrest, hypoxia, occurs when the oxygen level drops in the body tissues. Oxygen is required to produce energy, and it helps tissues and organs perform their required function. Low oxygen levels for a long time (prolonged hypoxia) can damage your organs, such as the brain and heart. As per current research, hypoxia can cause a fall in blood pressure, leading to bradycardia (a slow heart rate) and finally progressing to a cardiac standstill.
The symptoms and causes of hypoxia include:
Symptoms | Causes |
When severe, hypoxia can cause additional symptoms, such as:
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Conditions that can cause hypoxia include the following:
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The following table shows the diagnosis and management of this reversible cause of cardiac arrest.
Diagnosis | Treatment |
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Fluids in the body are essential to keep the organs functioning. Hypovolemia occurs when your body loses fluids, such as blood or water. Out of the 50-60% fluid consistency in the body, you lose over 15% of fluids from the body during hypovolemia. Due to severe fluid loss, the heart stops pumping blood, and other organs stop functioning.
The symptoms and causes of hypovolemia include:
Symptoms | Causes |
Severe symptoms of hypovolemic shock include:
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Loss of blood or fluid from the body is the major cause of hypovolemia, which may occur due to the following:
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The diagnosis and treatment for hypovolemia include:
Diagnosis |
Treatment |
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The goal of hypovolemia treatment is to increase the amount of fluid in the body through fluid replacement, which includes:
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Electrolyte disorders, such as hyperkalaemia and hypokalaemia, are reversible causes of cardiac arrest. Hyperkalemia is a condition where the potassium level in the body is abnormally high, i.e., more than 5.5 mmol/L. Too much potassium in the body can damage the heart and cause a heart attack. On the other hand, hypokalaemia refers to a low blood potassium level in the body, i.e., below 2.5 mmol/L. Over time, low potassium levels can cause problems such as abnormal heart rhythm, muscle weakness, and paralysis.
The symptoms and causes of hyperkalaemia and hypokalaemia include:
Symptoms | Causes | |
Hyperkalaemia |
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Hypokalaemia |
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The diagnosis and treatment for hyperkalaemia and hypokalaemia include:
Diagnosis | Treatment | |
Hyperkalaemia |
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Hypokalaemia |
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Hypothermia is an emergency condition in which the body produces less heat than it loses heat, leading to an extremely low body temperature. As opposed to the normal body temperature of about 98.6℉, the body temperature falls below 95℉ in hypothermia. This severe fall in body temperature can cause complete heart failure and eventually lead to death.
The symptoms and causes of hypothermia include:
Symptoms | Causes |
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Cold weather conditions or prolonged exposure to an environment colder than your body are the primary causes of hypothermia. Conditions that lead to hypothermia include:
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The diagnosis and treatment of hypothermia include:
Diagnosis | Treatment |
The diagnosis of the condition is generally apparent based on the person’s physical signs. The doctor may order blood tests to confirm hypothermia and its severity. |
The treatment aims to increase body temperature to a normal range. The treatment options include:
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The "4 Ts" of reversible causes of cardiac arrest are Toxins, Trauma, Tamponade and Thrombosis:
Tension pneumothorax is the first ‘T’ of 4H and 4T in cardiac arrest. This condition develops when air builds up in the pleural space (between the lungs and inside the chest cavity). This buildup of air causes a shift in the mediastinum (space in the chest that holds the heart and other important structures), leading to haemodynamic compromise.
The symptoms and causes of tension pneumothorax include:
Symptoms and Signs |
Causes |
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The diagnosis and treatment for this reversible cause of cardiac arrest include:
Diagnosis |
Treatment |
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Thrombosis is one of the 8 reversible causes of cardiac arrest. It is a serious condition in which one or more blood clots form in the blood vessels, obstructing the blood flow. The two types of thrombosis that generally cause cardiac arrest include coronary thrombosis and pulmonary embolism. Coronary thrombosis occurs when blood clots block the coronary artery in the heart, often leading to a heart attack or stroke. On the other hand, pulmonary embolism occurs when the blood clots block a pulmonary artery in the lungs.
The symptoms and causes of coronary and pulmonary thrombosis include:
Symptoms | Causes | |
Coronary Thrombosis |
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It is caused by the breakage or rupture of plaque in the arteries. Plaque in the arteries is formed by cholesterol in the blood. |
Pulmonary Embolism |
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It is most often caused by deep vein thrombosis. Several causes for blood clots in deep veins include:
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The diagnosis and treatment for thrombosis include:
Diagnosis | Treatment | |
Coronary thrombosis |
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Pulmonary embolism |
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Cardiac tamponade is the next ‘T’ in 4H and 4T of cardiac arrest. It occurs when fluid builds up in the pericardium (the sac that encloses the heart). As a result, this puts pressure on the chest leading to cardiac arrest. If not treated, cardiac tamponade is always fatal.
The symptoms and causes of tamponade include:
Symptoms | Causes |
Signs include:
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It can also be caused due to several diseases and conditions, such as:
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The diagnosis and treatment of tamponade include:
Diagnosis | Treatment |
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Self-poisoning with toxins is the last reversible cause of cardiac arrest that obstructs the airway and causes respiratory arrest. While toxins in small amounts can be helpful, they can become poisonous in large amounts. Cardiac arrest caused due to toxins is rare. However, people suffering from this condition can benefit from an adequate resuscitation attempt.
The symptoms and causes of toxin buildup in the body include:
Symptoms | Causes |
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The following table shows the diagnosis and treatment of toxin overload:
Diagnosis |
Treatment |
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The basis of cardiopulmonary resuscitation (CPR) is to encourage the return of spontaneous circulation (ROSC). It involves restarting the heart with proper electrical signals and blood flow to the body. If left unchecked, the reversible causes of cardiac arrest can cause a prolonged interval between the arrest and ROSC, decreasing the chances of survival. Therefore, it is important to treat these causes in the minutes following cardiac arrest.
It is important to understand the above-mentioned reversible causes of cardiac arrest. Why? Because treating these causes can improve the chances of survival after a cardiac arrest. Understanding these causes and their management is key to optimal care that will likely lead to positive outcomes.
If you have any more doubts about the 4H and 4T in cardiac arrest, you can contact an HexaHealth expert TODAY! Our team will connect you with the right doctors for appropriate treatment.
The 8 reversible causes of cardiac arrest include:
The 5H and 5T of cardiac arrest is a way to remember the reversible causes, which include:
CPR with compressions should be given when there is no breathing or pulse. However, when the patient has a pulse but is not breathing properly, ventilation should be provided without compressions (rescue breathing). For adults, one breath should be given every five to six seconds. For children, one breath should be given every three to five seconds.
No, CPR cannot restart a stopped heart. It is only a temporary measure to provide a minimal supply of oxygen to your brain and other organs. Defibrillation is the only effective way to re-establish a regular heartbeat during cardiac arrest.
Doctors hit the chest or perform a precordial chest thump before CPR in response to witnessed ventricular fibrillation or ventricular tachycardia. It aims to restore organised electrical cardiac activity and move the patient to a more stable rhythm.
If CPR is performed within six minutes of cardiac arrest, the brain might survive the lack of oxygen. However, after six minutes without CPR, the brain begins to die. The greatest chance of survival and keeping the brain alive is within 16 to 24 minutes of cardiac arrest. With new advances such as mechanical CPR, the brain can stay alive and see more positive outcomes for more than 20 minutes.
The CPR survival rate is about 12% for cardiac arrests outside the hospital. On the other hand, the survival rate is between 24% and 40% for cardiac arrests in the hospital.
A non-reversible cause of cardiac arrest is a condition that cannot be treated or reversed, resulting in the individual's death. Some examples of non-reversible causes of cardiac arrest include sudden cardiac death, traumatic injury, an overdose of certain drugs, and Severe blood loss.
The 5 H's refer to five common causes of cardiac arrest: Hypoxia, Hypovolemia, Hydrogen ion (acidosis), Hyperkalemia, and Hypothermia.
Last Updated on: 16 January 2023
MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES
12 Years Experience
Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More
MSc. Clinical Research I PG Diploma in Public Health Services Management
3 Years Experience
His work in medical content writing and proofreading is noteworthy. He has also contributed immensely to public health research and has authored four scientific manuscripts in international journals. He was assoc...View More
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