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Ulcerative Colitis: Symptoms, Diagnosis, Risks & Treatment

Medically Reviewed by
Dr. Aman Priya Khanna
Ulcerative Colitis

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Ulcerative Colitis
Medically Reviewed by Dr. Aman Priya Khanna Written by Sparshi Srivastava

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According to a study by Rupa Banerjee et al. in 2023, ulcerative colitis contributed to 2.2% of all inflammatory bowel disease cases. These findings show the significant healthcare burden associated with the condition. But how do you know if you are suffering from it? 

Ulcerative colitis symptomsmay not be noticeable initially and become problematic later. Persistent changes in your digestive health or bowel habits may indicate worsening issues. Learn about the symptoms, diagnosis, treatment, and more.

Disease Name

Ulcerative Colitis

Symptoms

  1. Diarrhoea

  2. Exhaustion

  3. Abdominal discomfort and cramps

Risk Factors

  1. Stress

  2. Poor immune system

  3. Family history

Diagnosis

  1. Blood tests

  2. Stool test

  3. Colonoscopy

Treated by

Gastroenterologist

Treatment Options

  1. Medications

  2. Surgical options

What is Ulcerative colitis?

Colitis is the inflammatory response in the colon (large intestine). It is the final portion of the gastrointestinal tract, and the rectum is found just below it. The swelling in this lining causes abdominal pain, cramps, bloating, and blood in the stool. 

In ulcerative colitis (UC), the chronic response in the body progresses to the formation of sores or ulcers. It can cause frequent bowel movements and sometimes mucus or pus discharge.

Ulcerative Colitis Types

Doctors classify UC based on the affected area. Typically, the inflammation starts in the rectum, closest to the anus, and may spread further along the colon. 

Colitis Types

Inflammation Location

Ulcerative Proctitis

Rectum 

Proctosigmoiditis

Rectum and sigmoid colon (lower S-shaped section)

Left-Sided Colitis

Sigmoid and left portion of the colon 

Pancolitis

Rectum and complete colon 

Ulcerative Colitis Symptoms and Signs

Ulcerative colitis symptoms can gradually worsen over time. The following are the signs and symptoms of people with inflammatory colitis:

Early Signs (Mild):

  1. Diarrhoea (with or without blood)

  2. Increased bowel movements and tenesmus (urge to defecate but no stool discharge) (up to 4 times a day)

  3. Mild cramping or abdominal discomfort

Later Signs (Moderate to Severe):

  1. Frequent bowel movements (4 or more times a day)

  2. Blood, mucus, or pus in stool

  3. Severe cramping

  4. Extreme tiredness (fatigue)

  5. Unexpected weight loss

  6. Nausea

  7. Fever

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Ulcerative Colitis Risk Factors

The actual cause of ulcerative colitis is still unknown. However, it can be triggered by various risk factors. It can be classified as controllable and uncontrollable factors. 

Uncontrollable Aspects:

  1. Age: Generally diagnosed between 15 and 35 years old, with a secondary peak in those between 50 and 75.

  2. Family History: Having a close relative (parent, sibling, child) with colitis significantly raises your risk.

  3. Immune System Dysfunction: In UC, the defensive mechanism of the body seems to malfunction. It mistakenly identifies harmless substances in the gut as threats, leading to chronic inflammation.

Controllable Aspects:

  1. Diet: High intake of polyunsaturated fatty acids might contribute to digestive problems.

  2. Lifestyle: A sedentary lifestyle can negatively impact your overall health, including gut health.

  3. Appendectomy: In some cases, it was found that removing appendix lowers risk of ulcerative colitis but increases chances of Crohn's disease.

Prevention of Ulcerative Colitis

While there isn't a confirmed method to prevent ulcerative colitis, maintaining a balanced diet can help to manage its symptoms.

  1. Keep the meal portions small.

  2. Stay hydrated.

  3. Identify specific triggers with a food journal.

  4. Take vitamins and supplements if needed due to nutrient absorption issues.

  5. Certain pain medications (NSAIDs) may worsen symptoms. Discuss alternatives with your doctor.

Note: This information is a general guideline and shouldn't replace consulting a healthcare professional.

How is ulcerative colitis diagnosed?

Ulcerative colitis can mimic other bowel conditions. This makes ulcerative colitis diagnosis crucial for proper treatment. The common tests doctors might use to identify the condition include:

  1. Blood Tests: These check for signs of anaemia (low RBC count) due to bleeding. Inflammation markers like C-reactive protein and erythrocyte sedimentation rate (ESR) are also checked. 

  2. Stool Test: This analyses your stool sample to detect inflammatory markers, bacteria, and parasites to rule out other causes.

  3. Flexible Sigmoidoscopy: A flexible, thin tube with a camera is inserted through the rectum. It is to examine the lower part of your colon (sigmoid colon) and part of the descending colon.

  4. Colonoscopy: This uses a longer, lighted scope called a colonoscope inserted through the rectum. It is to examine the entire length of your colon.

  5. Biopsy: A tiny tissue sample from the colon may be taken during an endoscopy. It is examined under a microscope to confirm inflamed and ulcerated mass.

How to prepare for the doctor's consultation?

A doctor's consultation is vital in managing ulcerative colitis. Below are the steps that would help you prepare for an informative discussion:

  1. Prepare Medical History: Compile a list of all medicines you take, including prescriptions, OTC drugs, and supplements. 

  2. Track Symptoms: Record details like frequency of bowel movements, presence of blood in stool, abdominal pain intensity, and any other discomfort you experience.

Ulcerative Colitis Treatment

Ulcerative colitis treatment focuses on regulating the immune system. It helps manage the condition. It necessitates a multifaceted approach, which is as follows:

Non-Surgical Methods

These are available to manage the condition and can help to improve the quality of life.

  1. Medications: This works to calm down inflammation in the colon. It helps the tissue to heal and reduces symptoms like diarrhoea, bleeding, and stomach pain. These also prevent future flare-ups, leading to longer periods of wellness. 

  2. Dietary modifications: A bland, nutrient-rich diet promoting healing and symptom reduction is crucial. Doctors may recommend lactose restriction for those with intolerance and a focus on easily digestible foods.

Proctocolectomy

This surgery involves removal of a part or complete colon and rectum. It can be done with two approaches:

  1. With Ileal Pouch: The surgeon creates a pouch, which is a section of the small intestine attached to the anus. Once healed, it acts as a new rectum, allowing normal bowel movements. 

  2. With Ileostomy:  A small opening is made in the abdomen, and a bag (ileal stoma) is created outside the body to collect waste. 

Estimated Cost of Ulcerative Colitis 

The cost of treating ulcerative colitis ranges depends majorly on the technique used. If proctocolectomy is done with an ileal pouch, then the price ranges from ₹ 1,50,000 - ₹ 2,00,000. While ileostomy can be around ₹ 1,25,000 - ₹ 1,50,000.

Procedure Name 

Estimated Cost Range 

Proctocolectomy with Ileal Pouch

₹ 1,50,000 - ₹ 2,00,000

Proctocolectomy with Ileostomy

₹ 1,25,000 - ₹ 1,50,000

Note: The figures mentioned above are approximations and can vary due to variables like chosen hospital, surgeon, etc. Contact HexaHealth for accurate information and price quotation.

Risk of Delay in Ulcerative Colitis Treatment

Ulcerative colitis usually doesn't improve over time. If left untreated, symptoms can stay or get even worse. It could lead to the following health conditions:

  1. Uncontrolled Inflammation: The swelling in the colon can worsen and spread, making it harder to manage the disease later.

  2. Nutritional Issues: You may experience malnutrition due to trouble absorbing nutrients, leading to symptoms like:

  1. Loss of appetite

  2. Swollen belly

  3. Fatigue

  4. Unintentional weight loss

  1. Anaemia: Blood loss from ulcers can cause anaemia, making you feel tired and weak.

  2. Increased Risk of Infections: Dehydration and malnutrition can impair the immune system, making you more prone to infections.

  3. Colon Cancer: A 2019 study concluded that the risk of colon cancer escalates over time for UC patients. The rates were 0.7%, 1.3%, and 2% after 1–9 years, 10–20 years, and 21–30 years, respectively.

Diet for Ulcerative Colitis

There is no specific ulcerative colitis diet for anyone as the response can vary for every individual. Generally following food items might be helpful in this condition are: 

  1. Omega-3-rich foods: These have anti-inflammatory properties and are potentially helpful during inflammatory colitis flares. Examples include:

    1. Fatty fish like salmon, mackerel, tuna

    2. Walnuts, flaxseeds, chia seeds

  1. Probiotics: Example includes yoghurt with live and active cultures.

  2. Stay Hydrated

  3. Seek Nutritional Support: Consider this if diet restrictions prevent meeting nutritional needs.

Foods to Limit During Ulcerative Colitis

Keep a food intake journal to identify foods that worsen your symptoms. These are general guidelines.

  1. Lactose: Milk, cheese, and yoghurt may trigger symptoms in some people. Consider lactose-free options if dairy is a problem.

  2. Red & Processed Meats: Limit red and processed meats to help avoid worsening symptoms.

  3. Alcohol: Beer, wine, and liquor may trigger flares for some.

  4. Carbonated Drinks: Soda and fizzy drinks can irritate your digestive system and cause gas.

  5. Sugar Alcohols: Found in sugar-free products like gum and candy, these can trigger symptoms. Be mindful of natural sugar alcohols in some fruits as well.

  6. Insoluble Fibre: Raw veggies like broccoli, whole grains, nuts, and fruits with skin can worsen cramping, bowel movements, and gas.

  7. Sugary Foods: Cakes, pastries, candy, and juices may trigger colitis.

  8. High-Fat Foods: Limit full-fat dairy, coconut, and processed foods high in palm oil.

  9. Spicy Foods: Hot peppers, chillies, and spicy sauces may trigger or worsen flares.

  10. Gluten (for some): Wheat, rye, and barley can be problematic. Consider a gluten-free diet if you suspect gluten is a trigger.

Takeaway

Ulcerative colitis is a chronic IBD (inflammatory bowel disease) associated with inflammation in the inner lining of your large intestine. Effective measures can help manage and achieve long-term relief. Early detection and timely treatment are crucial to prevent complications. 

HexaHealth guides you about the causes and ulcerative colitis symptoms along with top-tier hospitals and experts. We offer 24*7 assistance and personalised guidance. So, contact HexaHealth and take charge of your gut health today!

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FAQs for Ulcerative Colitis

Ulcerative colitis is a chronic issue that affects the large intestine. It causes inflammation and sores or ulcers to develop on the inner lining. Common symptoms include blood in bowel movements, diarrhoea and abdominal cramping.

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Ulcerative colitis symptoms may differ from person to person and may worsen over time. Here's a breakdown of what you might experience:

  1. Diarrhoea

  2. Increased bathroom trips

  3. Mild cramping or abdominal tenderness

  4. Belly aches, especially in the lower left area

  5. Blood, mucus, or pus in your stool

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The exact ulcerative colitis causes are unknown. Researchers suspect an overactive immune system plays a role. Genetic factors also trigger this in a few people.

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A proper diagnosis is the first step to controlling your gut health. The doctor will discuss your symptoms and family history. Below are the tests doctors use to diagnose:

  1. Blood tests

  2. Stool test

  3. Flexible sigmoidoscopy

  4. Colonoscopy

  5. Biopsy

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Ulcerative colitis treatment fights inflammation and flare-ups. It can be categorised as :

  1. Non-Surgical Methods:

    1. Medicines: It reduces cramps and diarrhoea to get you feeling better.
    2. Diet changes: This can help prevent future flare-ups.
  1. Surgical Methods: Involves partial or complete colon removal with internal or external pouch for waste collection.

Note: Consultation with a doctor is needed to find out the best options suitable.

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Medications and diet modifications can effectively manage symptoms and induce long-term remission. Surgery to remove the patient's colon and rectum is a definitive solution especially for severe cases.

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Ulcerative colitis and Crohn's disease are both chronic inflammatory bowel diseases (IBD). Some prominent differences between ulcerative colitis and Crohn's disease are given below:

Features

Ulcerative Colitis

Crohn's Disease

Location

The inner lining of the large intestine.

Patchy inflammation throughout the digestive tract.

Depth of Inflammation

Innermost layer

All layers of the digestive tract wall

Common Symptoms

Bloody diarrhoea

Abdominal pain, fatigue, weight loss

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Ulcerative colitis diet can vary by person. Below are the general dietary tips that can help manage symptoms and flares. 

  1. Small Frequent Meals: Consume smaller meals more often throughout the day instead of large, heavy meals.

  2. Listen to Your Body: Pay close attention to how your body reacts to different foods and adjust your diet accordingly.

  3. Consult a Dietitian: A dietitian can create a personalised diet plan that meets your nutritional needs and helps manage your UC.

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The medication used will depend on the severity of the condition. Ulcerative colitis treatment typically involves several medication classes:

  1. Aminosalicylates (5-ASAs): Reduce colon inflammation.

  2. Corticosteroids: Quickly reduce inflammation during flare-ups.

  3. Immunomodulators: Suppress the immune system to control inflammation.

  4. Biologics: Target specific immune system proteins involved in inflammation.

  5. JAK Inhibitors: Newer medications targeting immune system pathways.

Note: Consult your gastroenterologist or healthcare provider for personalised treatment recommendations. Avoid self-medication.

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Ulcerative colitis during pregnancy can lead to being underweight. Additionally, lacking essential nutrients increases the risk of miscarriage in the first trimester. Being underweight may also result in having a premature and underweight baby.

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Identifying and understanding risk factors is important for the prevention, early detection, and management of ulcerative colitis. Factors that may increase the likelihood of this condition include:

  1. Sex

  2. Family history

  3. Race and ethnicity

  4. Smoking

  5. Appendectomy

  6. Environmental triggers

  7. Diet and lifestyle

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Ulcerative colitis cannot be cured naturally. While there isn't a permanent fix, natural approaches can help manage symptoms and potentially reduce flare-ups. The natural approaches include:

1 Probiotics: These live bacteria promote gut health. 

2. Dietary Changes: Lifestyle changes can sometimes provide symptom relief:

  1. Stay hydrated.

  2. Take supplements for Vitamin D and calcium to avoid deficiencies.

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Research suggests a strong connection between ulcerative colitis and an increased risk of developing colorectal cancer. People with UC are six times more likely to get some form of this cancer compared to those without UC.

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Ulcerative colitis is a serious condition. Leaving it untreated can have significant consequences. The health risks associated with it are as follows:

  1. Uncontrolled inflammation (worsening and spreading)

  2. Nutritional issues

  3. Colon cancer

  4. Liver and kidney problems

  5. Bone loss

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Individuals with ulcerative colitis should have regular follow-up appointments to monitor their condition. This is to assess their risk of colon cancer. The frequency of these appointments depends on the extent of UC. For every 1-2 years, frequent colonoscopies are recommended. This is particularly true for UC involving areas beyond the rectum, the entire or the left side of the colon.

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Yes, you can find a wealth of support and resources for ulcerative colitis. Online and in-person support groups connect you with others facing similar challenges. For more information, contact HexaHealth experts.

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The cause of ulcerative colitis remains unknown, and there's no guaranteed way to prevent it. Good nutrition can be a powerful tool in managing the disease. 

The dietary changes below can help:

  1. Avoiding carbonated beverages.

  2. Limiting high-fibre foods like popcorn, vegetable skins, and nuts during flare-ups.

  3. Increasing fluid intake to stay hydrated.

  4. Eating smaller but frequent meals throughout the day.

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Stress isn't the direct cause of ulcerative colitis. However, it can make ulcerative colitis symptoms worse over time. 

Research suggests stress might:

  1. Damage to the gut lining

  2. Disrupt the gut microbiome (healthy bacteria balance)

  3. Affect digestive muscle function (speeding up or slowing down)

  4. Increase gut sensitivity to pain

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Genetics influence ulcerative colitis. If a person has family members with UC or Crohn's disease, their risk of developing the condition increases. Scientists have identified certain genes and chromosome regions linked to UC. These genes can affect how the immune system reacts.

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Medications are the first line of defence for ulcerative colitis. But if they don't work well, surgery might be an option. The surgery removes the inflamed part of your colon. Surgery might also be needed due to:

  1. Severe bleeding

  2. Colon perforation

  3. Toxic megacolon (severe colon inflammation that impairs function)

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Smoking decreases the likelihood of developing ulcerative colitis. Nicotine or other compounds in tobacco may prevent UC by producing carbon monoxide, which has anti-inflammatory effects. 

Note: Using smoking as a means to prevent ulcerative colitis should be avoided. As it raises the risk of developing Crohn's disease and worsen it.

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References

All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.


  1. Cleveland Clinic. Ulcerative Colitis [Internet]. Cleveland Clinic. 2020.link
  2. Everything You Need to Know If You Have Ulcerative Colitis (UC) [Internet]. Healthline. 2020.link
  3. Ulcerative Colitis Treatment Options [Internet]. Crohn’s & Colitis Foundation.link
  4. Can You Cure Ulcerative Colitis? An Expert Weighs In [Internet]. Healthline. 2021.link
  5. https://www.facebook.com/WebMD. Crohn’s and Colitis: What’s the Difference? [Internet]. WebMD. 2023. link
  6. Ulcerative colitis diet: Foods to eat and avoid [Internet]. www.medicalnewstoday.com. 2020 [cited 2024 Apr 4].link
  7. Untreated ulcerative colitis: Risks and complications [Internet]. www.medicalnewstoday.com. 2019 [cited 2024 Apr 4].link
  8. Ulcerative Colitis Medications: Biologics, What to Avoid, and More [Internet]. Healthline. 2021 [cited 2024 Apr 4].link
  9. Watson S. Ulcerative Colitis and Pregnancy [Internet]. WebMD. link
  10. Ulcerative colitis Information | Mount Sinai - New York [Internet]. Mount Sinai Health System. [cited 2024 Apr 4].link
  11. Natural remedies for ulcerative colitis [Internet]. www.medicalnewstoday.com. 2020.link
  12. McDade S. How Ulcerative Colitis Affects Your Colon Cancer Risk [Internet]. WebMD. [cited 2024 Apr 4].link
  13. Ulcerative colitis - Diagnosis and treatment - Mayo Clinic [Internet]. www.mayoclinic.org. [cited 2024 Apr 4].link
  14. The Best Resources for Ulcerative Colitis (UC) [Internet]. Healthline.link
  15. Articles [Internet]. Cedars-Sinai.link
  16. Wiginton K. The Link Between Stress and Ulcerative Colitis [Internet]. WebMD.link
  17. Alexandra Benisek. Smoking and Ulcerative Colitis: What’s the Link? [Internet]. WebMD. 2022.link
  18. Does ulcerative colitis affect your colon cancer risk? [Internet]. www.medicalnewstoday.com. 2023 [cited 2024 Apr 4].link

Last Updated on: 22 April 2024

Disclaimer: The information provided here is for educational and learning purposes only. It doesn't cover every medical condition and might not be relevant to your personal situation. This information isn't medical advice, isn't meant for diagnosing any condition, and shouldn't replace talking to a certified medical or healthcare professional.

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Sparshi Srivastava

Sparshi Srivastava

B.Tech Biotechnology (Bansal Institute of Engineering and Technology, Lucknow)

2 Years Experience

An ardent reader, graduated in B.Tech Biotechnology. She was previously associated with medical sciences secondary research and writing. With a keen interest and curiosity-driven approach, she has been able to cont...View More

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