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SGPT and SGOT Levels in Jaundice

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Medically Reviewed by Dr. Aman Priya Khanna
Written by Charu Shrivastava, last updated on 9 July 2024| min read
SGPT and SGOT Levels in Jaundice

Quick Summary

  • SGOT and SGPT are enzymes mainly produced by the liver cells.
  • Jaundice occurs due to the increased production of bilirubin.
  • SGOT and SGPT levels are unrelated to jaundice but may indicate a liver disease that has caused jaundice.

SGOT or AST (aspartate aminotransferase) and SGPT or ALT (alanine aminotransferase) are enzymes mainly produced by the liver cells. When the liver or its cells are damaged due to any disease, SGOT and SGPT stored in the liver cells get released in the blood. This is why, when someone suffers from liver disease, their liver function test report may show elevated liver enzymes. Therefore, the level of these enzymes in the blood is an indicator of liver health. Jaundice is again a condition that indicates that there may be something wrong with the liver. 

Jaundice occurs due to the increased production of bilirubin - a yellow pigment that forms during the breakdown of red blood cells. When total bilirubin is more than 1.2 mg/dL, it may indicate jaundice. So, SGOT and SGPT levels are unrelated to jaundice but may indicate a liver disease that has caused jaundice. 

To understand the significance of SGOT and SGPT levels in jaundice, it is important to first know about this condition and its underlying causes. 

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What Is Jaundice?

It is a condition in which the skin and the whites of the eyes turn yellow. The colour yellow is due to the presence of a high level of bilirubin in the blood. 
Bilirubin is a yellow-orange pigment produced when the liver breaks down haemoglobin. It is excreted in bile through the liver and is eventually passed out of the body. 
But if there is damage in the liver, it fails to filter it from the bloodstream, leading to the buildup of bilirubin that gradually starts reflecting in the colour of the skin and sclera (white of the eyes).
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How Is It Caused?

Jaundice is caused when the liver fails to remove bilirubin from the blood. Bilirubin is found in red blood cells (RBCs). When the liver breaks down old or damaged RBCs, it also filters out bilirubin from the blood, which gets produced as the end product of the breakdown. However, several conditions, including diseases and certain medications, may disable the liver from doing so. This can lead to jaundice. 
SGPT and SGOT levels in jaundice can be indicators of the following underlying conditions:- 
  1. Hepatitis - Inflammation in the liver is known as hepatitis. In most cases, this condition is caused due to a virus. However, certain medications, autoimmune disorders, and heavy alcohol can also cause hepatitis. The inflammatory condition of the liver can affect its normal functioning. If this condition remains untreated for a long time, it may damage the liver and cause jaundice. 
  2. Alcohol-Induced Liver Disease - When a person drinks high amounts of alcohol that his or her liver cannot process, it can lead to severe damage. Alcohol-induced liver diseases can progress to three stages over time, depending on the amount of alcohol consumption. 
  3. Fatty Liver - Anyone who drinks excess alcohol may experience a buildup of fats inside the liver cells leading to fatty liver. It is the most common alcohol-induced liver disease. 
  4. Alcoholic Hepatitis - It occurs when there is acute liver inflammation due to heavy alcohol use for many years. This condition may lead to the death of the liver cells, and it may even cause permanent scarring. 
  5. Alcoholic Cirrhosis - In this stage, the liver is significantly scarred and is generally not reversible. However, avoiding alcohol consumption can prevent further damage. 
  6. Autoimmune Hepatitis - This condition occurs when the body’s immune system attacks healthy liver cells by mistake. It can also seriously damage the liver resulting in jaundice. 
  7. Non-Alcoholic Fatty Liver Disease - People who aren’t heavy drinkers may also have fatty liver disease. Those with obesity and diabetes are at an increased risk of this disease. 
Other reasons for jaundice can include:- 
  1. Blockage in the thin tubes (bile ducts) that carry bile from the liver to the gall bladder and eventually to the small intestines. 
  2. Pancreatic cancer - It can lead to blockage in the bile ducts resulting in jaundice. 
  3. The use of medications, such as acetaminophen, birth control pills, and steroids, may also result in liver disease. 
  4. Rare genetic metabolic defects also sometimes affect the normal functioning of the liver.

Symptoms

The symptoms of jaundice may vary depending upon its underlying cause. In some cases, the patients may not even experience the symptoms of jaundice. However, if jaundice is caused due to an infection and is temporary, it can lead to the following symptoms:- 
  1. Change in skin colour
  2. Dark coloured urine
  3. Fever
  4. Chills
  5. Abdominal pain 
When jaundice occurs due to liver disease, you may experience the following symptoms:- 
  1. Chronic hepatitis - inflammation of the liver
  2. Acute hepatitis A, B, or C
  3. Inflammation of the joints
  4. Pyoderma Gangrenosum - a condition that causes large and painful sores on the skin 

How Is It Diagnosed?

To diagnose jaundice, the doctor first asks about the symptoms and medical history of the patient. He or she performs a physical exam to check the signs of liver disease and order lab tests to find the underlying cause. The lab tests may include:
  1. Bilirubin Tests: To measure the level of bilirubin present in your blood. 
  2. Complete Blood Count (CBC) Test: To evaluate the level of red blood cells, white blood cells, and platelets in your blood. 
  3. Hepatitis A, B, or C Tests: To check the presence of a liver infection. 
If you have high SGPT and SGOT levels in jaundice, it may be an indicator of liver disease. You must consider the above tests to rule out hepatitis and other infections or diseases. SGOT and SGPT levels do not directly help diagnose jaundice, but they may point out a liver infection or disease which may lead to jaundice.

SGPT and SGOT Levels in Jaundice

In the case of liver disease or damage, a person may experience several signs, such as elevated liver enzymes (including Alkaline phosphatase, AST, and ALT) and increased bilirubin in the blood. Both these conditions indicate that the liver is not functioning normally. This is why high levels of SGOT and SGPT in jaundice suggest a possible liver infection or disease. 
It has become clear that SGOT and SGPT levels in the blood are not due to jaundice. So, the type and severity of the symptoms of jaundice depend on the underlying cause of liver damage rather than the levels of SGOT and SGPT. 

Conclusion

Usually, jaundice doesn’t bear any life-threatening risks and can be easily managed with medications. But if high levels of SGPT and SGOT in jaundice are detected, you should consult a doctor immediately for a further checkup to diagnose the underlying cause in time. 


In case you want to ask any queries or doubts related to your medical condition, our experts at Hexa Health can help you find the right solution. The Hexa Health team includes well-trained and skilled professionals who can provide accurate guidance regarding your disease along with proper treatment advice. So, connect with a Hexa Health expert today!

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Frequently Asked Questions

Jaundice is a condition in which the colour of the skin and white of the eyes becomes yellow in colour due to the presence of an excess amount of bilirubin in the blood. Bilirubin is a yellow-orange pigment filtered from the blood through the liver. Certain medications, infections, or liver diseases can disable the liver from removing bilirubin from the blood leading to its buildup.
If the ratio of SGOT and SGPT levels is more than 2, it may indicate liver diseases, such as cirrhosis or alcoholic hepatitis. Jaundice may be a symptom of these liver diseases, but the levels of SGOT and SGPT in the blood are not directly linked to jaundice. Therefore, the level of SGOT and SGPT in jaundice depends on the severity of its underlying cause.
High levels of SGOT and SGPT can be due to any of the following conditions:
  1. Obesity 
  2. Excessive alcohol consumption 
  3. Acute viral hepatitis 
  4. Autoimmune disorders
  5. Heartattack 
  6. Diabetes 
  7. Muscle injuries
High SGOT and SGPT levels and jaundice are indicators of liver infection or disease. But SGOT and SGPT levels are not directly related to jaundice.
Jaundice happens when the liver fails to remove bilirubin (a yellow pigment produced during the breakdown of RBCs) from the blood. Hence, if the level of bilirubin in the blood is more than normal, it may indicate that the patient has jaundice. 
The normal level of bilirubin is:- 
  1. Direct or conjugated bilirubin: less than 0.3 mg/dL
  2. Total bilirubin: 0.1 to 1.2 mg/dL
Persistent high levels of SGOT and SGPT in the blood may be due to chronic liver diseases, such as cirrhosis and alcoholic hepatitis. If the levels don’t come down, you may experience the following symptoms:
  1. Shortness of breath 
  2. Jaundice 
  3. Easy bruising and excessive bleeding 
  4. Weakness and tiredness
  5. Nausea
  6. Swelling in the legs and feet

Last Updated on: 9 July 2024

Disclaimer: The information provided here is for educational and learning purposes only. It doesn't cover every medical condition and might not be relevant to your personal situation. This information isn't medical advice, isn't meant for diagnosing any condition, and shouldn't replace talking to a certified medical or healthcare professional.

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Charu Shrivastava

Charu Shrivastava

BSc. Biotechnology I MDU and MSc in Medical Biochemistry (HIMSR, Jamia Hamdard)

2 Years Experience

Skilled in SEO and passionate about creating informative and engaging medical content. Her proofreading and content writing for medical websites is impressive. She creates informative and engaging content that educ...View More

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